Karen will bring a flood risk to Puerto Rico and the US and British Virgin Islands.
Virgin Islands National Park announced Sunday that Louisville's wife, Lucy Schuhmann, 48, has been missing in St. John since September 19.
A national park statement said Schuhmann was missing on Airbnb when she was staying at Coral in St. John.
"Schuhmann did not check out as planned, his belongings were in his room and his rented jeep was later found in the Salt Pond parking lot in the Virgin Islands National Park," the newspaper said.
US Coast Guard St. John Rescue, Virgin Islands Police, park officials and volunteers searched the ground and water for her, but approaching tropical storm Karen prevented them.
"Tuesday morning weather conditions are cloudy and rainy and are expected to deteriorate as tropical storm Karen approaches," the park said on Facebook. "A Tropical Storm Warning has been issued to the Virgin Islands, and search efforts are being suspended until the storm has passed and conditions allow the effort to continue safely."
On Monday, divers, snorkelers and a Coast Guard helicopter searched for Schuhmann in the waters off St. John's south coast, but found no sign of the missing woman.
Schuhmann's family asked for privacy, the park said. Anyone with information is asked to call 866-995-8467 and choose option two.
Contribution: Billy Kobin
Follow Sarah Ladd on Twitter: @ladd_sarah.
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